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Graph showing the percentage variation in body weight of mice after 70 days of treatment with PLX4720 (BRAFi) and PD0325901 (MEKi), combined with eFT226 (1 mg/kg).

Journal: bioRxiv

Article Title: Selective mRNA translation determines adaptative mutability of melanoma cells to anti-BRAF/MEK combination therapy

doi: 10.1101/2025.09.02.673634

Figure Lengend Snippet: Graph showing the percentage variation in body weight of mice after 70 days of treatment with PLX4720 (BRAFi) and PD0325901 (MEKi), combined with eFT226 (1 mg/kg).

Article Snippet: When tumors reached an average volume of 150 mm 3 , mice were fed with the control rodent diet or with diet supplemented with 200 ppm PLX4720 (BRAF inhibitor, Medchem Express) and 7 ppm PD0325901 (effective concentration of MEK inhibitor, Medchem Express). eFT226 (1 mg/kg, Medchem Express) or RBX0901 (1 mg/kg) were injected intraperitoneally two times per week for the entire duration of the experiment (70 days).

Techniques:

Graph showing the percentage variation in body weight of mice after 70 days of treatment with PLX4720 (BRAFi) and PD0325901 (MEKi), combined with RBX0901 (1 mg/kg).

Journal: bioRxiv

Article Title: Selective mRNA translation determines adaptative mutability of melanoma cells to anti-BRAF/MEK combination therapy

doi: 10.1101/2025.09.02.673634

Figure Lengend Snippet: Graph showing the percentage variation in body weight of mice after 70 days of treatment with PLX4720 (BRAFi) and PD0325901 (MEKi), combined with RBX0901 (1 mg/kg).

Article Snippet: When tumors reached an average volume of 150 mm 3 , mice were fed with the control rodent diet or with diet supplemented with 200 ppm PLX4720 (BRAF inhibitor, Medchem Express) and 7 ppm PD0325901 (effective concentration of MEK inhibitor, Medchem Express). eFT226 (1 mg/kg, Medchem Express) or RBX0901 (1 mg/kg) were injected intraperitoneally two times per week for the entire duration of the experiment (70 days).

Techniques: